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International Journal of Scientific and Engineering Research
ISSN Online 2229-5518
ISSN Print: 2229-5518 7    
Website: http://www.ijser.org
scirp IJSER >> Volume 3,Issue 7,July 2012
Insilico Designing And Development of Vaccine For V.Cholerae O139 In Cholera Disease
Full Text(PDF, )  PP.87-94  
Author(s)
Dr. Ramani Iyengar, Sriranjini A.S, Jasmine
KEYWORDS
ABSTRACT
V.cholerae was first isolated by Italian anatomist Filipo Panici. V.cholerae is the etiological agent of cholera, a major health concern in most of the developing countries. V cholerae carry strains the encode the cholera toxin. These cholera toxins enters the Epithial cells and after crossing host line of defense it starts colonizing itself in the small intestine. Cholera is usually a non contagious disease. The main aim of this project is to design and develop a vaccine against cholera. Vibrio Cholerae is a bacterium with 12,865 odd proteins causing cholera. Among these 1 protein sequence was selected having least identity and least E- value. It was then screened by using SDSC workbench tool. Then antigenic determinants were found by using different tools. The sequence with least identity was taken into consideration and then further designed and used for docking studies. From this Docking analysis the epitope molecule LEALVEDL was found to be the best vaccine candidate.
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