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International Journal of Scientific and Engineering Research
ISSN Online 2229-5518
ISSN Print: 2229-5518 4    
Website: http://www.ijser.org
scirp IJSER >> Volume 3,Issue 4,April 2012
Stimuli Sensitive Interpenetrating Network[
Full Text(PDF, )  PP.138-143  
Author(s)
Pham Trong Binh and Hsu, Hao-Chun and Zhao Zhenyu
KEYWORDS
Dye Absorption, Hydrogels, Interpenetrating Network, Nanoparticles, Polymers, Stimuli Sensitive, Swelling Synthetic Chemistry
ABSTRACT
Hydrogels are three-dimensional, cross-linked polymer networks that can absorb a large amount of water or solvent without dissolution. Due to their high absorbency, soft consistency and other properties, such materials can be used in medical industries to produce artificial organs, contact lenses, dressing for wound treatment and drug transporting devices. In this research poly(N-Vinylcaprolactam) (PVCL) hydrogels were synthesized with different cross-linkers. It was found that cross-linkers affected the stability of the hydrogel and those with high hydrophilicity enhanced its swelling capacity. Our experiments showed that ethylene glycol dimethylacrylate (EGDMA) was the ideal cross-linker. Hydrogels of an interpenetrating polymer network (IPN) composed of the thermo-sensitive PVCL and pH-sensitive poly(N-acryloyl-N'-ethylpiperazine) (PAcrNEP) were prepared via sequential polymerization. They were characterized for their thermo and pH-responsive behaviour by time dependence, equilibrium and oscillatory swelling studies. The results showed that these IPN successfully exhibited a combined pH and temperature-sensitivity at a temperature range of 20-35oC and a pH range of 3-6. This is a milestone in the study of hydrogels because most of them focused mainly on gels sensitive to basic medium only. The network also exhibited superior swelling capacity compared to pure PVCL even at high pH. Oscillatory swelling study showed that the IPN was able to respond to pH pulses quickly and reversibly. Dye absorption studies showed that IPN is a potential purifying agent. It was also found that the IPN is a good substrate for growing nanoparticle. Further research may include permeation studies of the IPN to test its ability for drug delivery
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