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International Journal of Scientific and Engineering Research
ISSN Online 2229-5518
ISSN Print: 2229-5518 2    
Website: http://www.ijser.org
scirp IJSER >> Volume 3,Issue 2,February 2012
CNS Inflammation and Epileptogenesis
Full Text(PDF, )  PP.5-9  
Author(s)
Francis I. Baffour
KEYWORDS
CNS Infections, Epileptogenesis, Fever, Immune Modulators, Inflammation, Mesial Temporal Lobe Epilepsy, Seizures
ABSTRACT
An association between acute CNS infections and seizures is reported in the literature. The etiology of these seizures is, in some cases, precipitated by epileptogenic pathogenesis of the infectious agent in the brain parenchyma. A different etiology of seizures as a consequence of infections, independent of the infectious agent, relates to the inflammatory reaction. Thirdly, the febrile response to infections may predispose the CNS to seizures due to the metabolic aberrations of fever. Febrile states have also been implicated in some cases of mesial temporal lobe epilepsy. Current attempts to control seizures with anti-inflammatory treatments have shown contrasting result, therefore specific agents need to be developed and tested.
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