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International Journal of Scientific and Engineering Research
ISSN Online 2229-5518
ISSN Print: 2229-5518 12    
Website: http://www.ijser.org
scirp IJSER >> Volume 2, Issue 12, December 2011
Restore islet β-cells dysfunction and study the expression of PPARα and PPARγ in Stevia rebaudiana treated mice
Full Text(PDF, 3000)  PP.  
Author(s)
Kosta Susmit, Tiwari Archana
KEYWORDS
Stevia rebaudiana (SR), Stevioside (SVS), Peroxisome proliferator-activated receptor alpha and Gamma (PPARα and PPARγ), Streptozotocin (STZ).
ABSTRACT
The down regulation of PPARα and PPARγ at m-RNAs expression level is responsible for β-cell dysfunction and insulin secretion seen in diabetic mice. PPAR α is found primarily in the liver and regulates genes involved with fatty acid utilization. PPARγ is an important regulator of adipocyte differentiation and function. Expression of the insulin sensitive glucose transporter, GLUT4, and the UCPs are also influenced by PPARγ. The current investigation focuses on expression of m-RNA at PPARα and PPARγ receptors and the islet β-cells dysfunction in Stevia rebaudiana (SR) treated diabetic mice.
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