Synthesis, Antibacterial and Antifungal Screening of Three new of Alpha-aminophosphonic acids [ ]

Due to the medicinal importance of α-aminophosphonic acid derivatives, the biological property of three synthesized α-aminophosphonic acids derivatives were screened in vitro against some Gram-positive and Gram-negative pathogenic bacteria and some pathogenic fungi. The results obtained are compared with those of the starting compounds. In this study, three compounds ([(4-Hydroxyphenyl) phosphonomethyl-amino]-methyl)-phosphonic acid (S1), ([(3-Hydroxyphenyl) phosphonomethyl-amino]-methyl)-phosphonic acid (S2) And ([(2-Hydroxyphenyl) phosphonomethyl-amino]-methyl)-phosphonic acid (S3) have been synthesized from 2-aminophenol (2AP), 3-aminophenol (3AP) and 4-aminophenol (4AP). The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were assessed by serial dilution technique. The synthesized compounds showed good antimicrobial and antifungal activity against all the tested organisms and the results are comparable to standard antibiotic chloramphenicol. The low MIC and MBC values and high sensitivity of pathogenic microorganisms to the compounds led to conclude that the α-aminophosphonic acids derivatives have potential antimicrobial and antifungal properties