Extent of DNA damage and changes in eGFR in hypertensive patients [ READ ]
Jithesh T K, Sreekanth P G, Shifa K, Parvathi K Warrier, Riju Mathew, T Vijayakumar
Hypertension(HTN) increases the risk for stroke and coronary heart disease and is a main contributor to mortality. Sustained HTN for an extended period of time can lead to DNA damage due to the oxidative stress or various other reasons. The genetic instability include mutations, chromosomal aberrations and/or unscheduled DNA synthesis. The GFR is the product of filtration rate in single nephron and the number of nephrons in both kidneys. Several formulae were developed for calculating GFR based on serum creatinine and other markers. Estimated GFR using creatinine was calculated by MDRD formula, Cockcroft – Gault formula and CKD – EPI cystatin equation. The GFR values were calculated using creatinine and compared with the eGFR using the newer biomarkers CysC. In vitro mutagen sensitivity analysis showed that the mean number of chromatid breaks per cell (b/c) was significantly higher in hypertensive patients than in controls. The mean number of chromatid breaks per cell (b/c) value correlated well with the eGFR values suggesting the influence if DNA damage in the pathogenesis in HTN.
Jithesh T K, Sreekanth P G, Shifa K, Parvathi K Warrier, Riju Mathew, T Vijayakumar
Hypertension(HTN) increases the risk for stroke and coronary heart disease and is a main contributor to mortality. Sustained HTN for an extended period of time can lead to DNA damage due to the oxidative stress or various other reasons. The genetic instability include mutations, chromosomal aberrations and/or unscheduled DNA synthesis. The GFR is the product of filtration rate in single nephron and the number of nephrons in both kidneys. Several formulae were developed for calculating GFR based on serum creatinine and other markers. Estimated GFR using creatinine was calculated by MDRD formula, Cockcroft – Gault formula and CKD – EPI cystatin equation. The GFR values were calculated using creatinine and compared with the eGFR using the newer biomarkers CysC. In vitro mutagen sensitivity analysis showed that the mean number of chromatid breaks per cell (b/c) was significantly higher in hypertensive patients than in controls. The mean number of chromatid breaks per cell (b/c) value correlated well with the eGFR values suggesting the influence if DNA damage in the pathogenesis in HTN.
