Discovery and Characterization of TAS-4: A Potent and Selective Metabotropic glutamate receptor 4 positive allosteric modulator im-proves movement in rodent models of Parkinson's disease [ ]

Parkinson’s disease (PD) is a very serious neurological disorder, and current methods of treatment fail to achieve long-term control. Previous studies suggest that stimulation of the metabotropic glutamate receptor 4 (mGluR4) represents a promising new approach to the symptomatic treatment of the Parkinson’s disease (PD). Preclinical models using both agonists and positive allosteric modulators of mGluR4 have demonstrated the potential for this receptor for the treatment of PD.