Assessment of risk factors concerning of systemic lupus erythamatosus on women and outcome of pregnancy at Karbala city [ ]

Background: Systemic lupus erythematosus (SLE) is a systemic inflammation autoimmune disease which can effect multiple systems of the human body. The underlying cause of SLE is not fully known, however, genetics, heredity, and environmental features are associated with the severity and outcome of the disease. SLE is a chronic disease that is more frequent in women of reproductive age. The relationship between lupus and pregnancy is problematic: maternal and fetal outcomes are worse than in the general population, and the management of flare-ups is difficult during this period. Objectives: The aim of the present work was ANA and anti-dsDNA to determine the prevalence of autoimmune in a cohort of Iraqi SLE woman patients and to describe their sites and relation to clinical characteristics, laboratory features and disease activity in pregnant women. Patients and Methods: A total of 30 patients with SLE (all patients were females) with ages ranged between (20 – 40) years were taken from (Al – Hassein Medical city/Karbala). Control group consisted of 20 healthy females who were free from signs and symptoms of SLE, with ANA tested by Immunofluorescence technique, also anti – dsDNA antibody was measured by enzyme linked immunosorbent assays kit supplied by (Euroimmune, Germany). C3 and C4 were measured using turbidimetry technique, their kits were supplied by(Vital Diagnostics , Italy ). Results: In the present study the ANA antibodies were positive in 100% of the cases. The mean value of anti – dsDNA (300.4±201.44) which shown in highly significance. In addition results showed that serum levels of C3 and C4 were low significantly in pregnant women of SLE in coparsion with those healthy in significant negative correlation between C3 and C4 levels in lupus. Conclusion: The effect of systemic lupus erythematosus on pregnant women are associated with high risk on pregnant itself and her baby in compeer with healthy pregnant women.Index Terms— Systemic lupus erythematosus, Antinuclear antibodies, Lupus pregnancy.