Clinical and Computational Study of Geometry & Heamodynamics of Arterial Stenosis
Full Text(PDF, 3000) PP.
| Author(s) |
|Krittika Dasgupta, Abhirup Roy Choudhury, Abhijit Chanda, Debabrata Nag|
| KEYWORDS |
Arterial flow, Clinical validation, Computational Fluid Dynamics, Heamodynamics, Mathemetical Modeling, Stenosis, Stenosis geometry.
Stenosis is abnormal narrowing of blood vessels. The presence of stenosis in arteries may cause critical flow conditions. It may finally lead to stroke and heart-attack. A clinical study has been done on more than 130 patients along with computational study using 2D axisymmetric rigid model of stenosis in the carotid artery. Assumed shapes of deposition zone and the degree of occlusion used in the analysis were taken from clinical data. The Navier-Stokes equations for incompressible fluid flow have been considered as the governing equations and it has been solved with varying flow parameters using standard CFD software package. The radial velocity profiles at various points of the flow field, the centerline velocity plot and the centerline pressure plots have been obtained from computational study and compared with the clinical data.
 D.N Ku., Blood flow in arteries. Ann. Rev. Fluid Mech.vol. 29, pp. 399-
 D.M Wootton., D.N.Ku., Fluid mechanics of vascular systems, diseases,
and thrombosis. Annu. Rev. Biomed. Eng. Vol.01, pp. 299-329, 1999.
 P.R. Johnston and D. Kilpatrick, Mathematical modeling of flow
through an irregular arterial stenosis. Journal of Biomechanics vol. 24,
pp. 1069-1077, 1991.
 H.I. Anderson, R. Halden, T. Glomsaker, Effects of surface irregularities
on flow resistance in differently shaped arterial stenosis. Journal of
Biomechanics vol. 33, pp. 1257-1262, 2000.
 D. Tang, C.Yang, D.N Ku., A 3-D thin-wall model with fluid-structure
interaction for blood flow in carotid artery with symmetric and asymmetric
stenosis. Computers and Structures vol. 72, pp.357-377, 1999.
 C. Bertolotti, V. Deplano, Three-dimensional numerical simulation of
flow through stenosed coronary bypass. Journal of Biomechanics vol.
33, pp. 1011-1022. 1999.
 P.K.Mandal, An unsteady anaysis of Non-Newtonian blood flow
through tapered arteries with stenosis. International Journal of Non-
Linear Mechanics vol. 40, pp. 151-164, 2005.
 A. Yakhot., L. Grinberg, N.Nikitin, Modeling rough stenoses by an
immersed-boundary method. Journal of Biomechanics vol. 38, pp. 1115-
 C.A Taylor., J.D Humphrey., Open problems in computational vascular
biomechanics: Haemodynamics and arterial wall stenosis. Comput.
Methods Appl. Mech. Engrg. Vol.198, 3514-3523, 2009.
 COMSOL Multiphysics User Guide.
 COMSOL Multiphysics Modelling Guide.
 Jay D. Humphrey, Sherry L. Delange, An Introduction to Biomchanics.