Association of TP53 [Arg72Pro] Gene Polymorphism and Breast Cancer Risk in Iraqi female patients [ READ ]
Anwar M. Al-janabi, Abdul Hussein A. Algenabi, Salih M. Alkhafaji, Imad Alsabri
Breast cancer is considered the first or second most common cancer and major cause of death in women globally. The TP53 tumor suppressor gene is one of the most commonly mutated genes in all types of human cancer including breast cancer. numerous studies showed that the significant association between Tumor suppressor protein TP53 gene polymorphism (Arg72Pro: rs 1042522) and the risk of breast cancer. We aimed to study and investigate the association of TP53 (Arg72Pro) gene polymorphism with the risk of breast cancer. The genotypes and allele frequencies of TP53 (Arg72Pro) gene polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 300 breast cancer patients and 200 controls after extraction of DNA from blood samples of all participants.
Anwar M. Al-janabi, Abdul Hussein A. Algenabi, Salih M. Alkhafaji, Imad Alsabri
Breast cancer is considered the first or second most common cancer and major cause of death in women globally. The TP53 tumor suppressor gene is one of the most commonly mutated genes in all types of human cancer including breast cancer. numerous studies showed that the significant association between Tumor suppressor protein TP53 gene polymorphism (Arg72Pro: rs 1042522) and the risk of breast cancer. We aimed to study and investigate the association of TP53 (Arg72Pro) gene polymorphism with the risk of breast cancer. The genotypes and allele frequencies of TP53 (Arg72Pro) gene polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 300 breast cancer patients and 200 controls after extraction of DNA from blood samples of all participants.
